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Identifying Xylazine in Drug Mixtures with Amplifi ID

​In July 2024 Spectra Plasmonics published a scientific white paper for xylazine detection. To download a copy of the PDF, please click here.

Below is a short summary of the paper.

Rising Rates of Xylazine in North America​

Rates of xylazine adulteration have increased throughout the unregulated drug supply in the United States. Xylazine is non-opiate sedative often used in veterinary medicine which does not respond to Narcan (Naloxone) due to its different mechanism of action. Ingestion can therefore lead to difficult-to-treat overdoses, especially when it is mixed with synthetic opioids like fentanyl.  Long term xylazine consumption has also been linked to other adverse effects such as skin lesions and severe wound formation. Consequently, there has been a surge in the need to detect these substances within drug samples and to monitor their proliferation within communities.

A partial screenshot of a table comparing the Amplifi ID Drug Analysis System and FTIR. Both were tested against real world samples containing substances such as fentanyl and xylazine

Preview: comparison between Amplifi ID and FTIR for detecting fentanyl and xylazine in street samples from our July 2024 white paper.

How Amplifi ID Addresses Xylazine Detection

This technical white paper dives into the scientific basis for Amplifi ID’s ability to detect xylazine in mixed drug samples, starting from the unique Raman and SERS spectral characteristics of the molecule compared to other noteworthy substances like fentanyl. Using both scientific reference standards and an analysis on real-world street samples, the paper outlines strong evidence for the technology to detect xylazine in combination with other drug molecules and cutting agents.  The paper also includes a comparison of how an FTIR instrument and Amplifi ID performed on detecting both fentanyl and xylazine within the street samples, with several instances of the molecules found below 5 wt.%.

A comparison of the Raman spectra of Fentanyl at Bulk (standard Raman) and Trace (SERS - 50ppm and 500ppm) levels with the Amplifi ID Drug Analysis system. The same comparison is done with Xylazine.

Raman spectra obtained with the Amplifi ID using both Bulk Scan and Trace Scan modes for a) pure fentanyl powder and b) pure xylazine powder. Surface Enhanced Raman Spectroscopy (SERS) substrates were tested by dissolving the pure powders in methanol to create 50 ppm and 500 ppm solutions.

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